Prevalence of diabetes mellitus in Chinese children with thalassaemia major.
Trop Med Int Health
; 22(6): 716-724, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28544032
ABSTRACT
OBJECTIVE:
Diabetes mellitus is a common endocrinopathy in patients with ß-thalassaemia major (ß-TM), which is high prevalent in southern China. This study aimed to determine the cause and prevalence of glycaemic disorders in Chinese children with ß-TM.METHODS:
In this prospective study, fasting glucose and insulin (FINS) levels were assessed in 267 ß-TM and 80 non-TM control children. Homeostatic model assessment (HOMA) and the quantitative insulin sensitivity check index (QUICKI) were evaluated. Iron overload was assessed by serum ferritin (SF), total units of blood transfused and cardiac T2*.RESULTS:
ß-TM had higher FPG (P < 0.001), FINS (P < 0.001) and HOMA-IR (P < 0.05), but lower QUICKI (P < 0.01) than those of controls. The impaired fasting glucose (IFG) was present in 30% of children, whereas 2% had diabetes. The prevalence of IFG in ß-TM group was higher in children aged >10 years (OR 6.5; 95% CI 3.7-11.4; P < 0.001), SF of >2500 µg/l (OR 4.8; 95% CI 2.1-11.1; P < 0.01), serum ALT levels of >50 IU/l (OR 2.1; 95% CI 1.2-3.7; P < 0.05) and cardiac T2* of <20 ms (OR 3.3; 95% CI 1.7-6.6; P < 0. 01). The children on deferiprone (DFP) had a reduced incidence of glycaemic aberrations than those on other chelating agents (OR 0.4; 95% CI 0.23-0.8; P < 0.05).CONCLUSIONS:
Our data suggest that IFG occurred in 30% of ß TM children, perhaps due to insulin resistance secondary to iron overload. Deferiprone-containing chelating agent may have a protective effect.Palavras-chave
Thalassemia major; cardiac load; carga cardiaca; charge cardiaque; courte taille; diabetes resistente a la insulina; diabète résistant à l'insuline; estatura baja; insulin resistance diabetes; iron overload; short stature; sobrecarga de hierro; surcharge de fer; thalassaemia major; thalassémie majeure
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Talassemia beta
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Sobrecarga de Ferro
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Diabetes Mellitus
/
Ferritinas
/
Insulina
/
Ferro
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Child
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Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article