MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis.

Lou, Guohua; Yang, Ying; Liu, Feifei; Ye, Bingjue; Chen, Zhi; Zheng, Min; Liu, Yanning

Lou, Guohua; Yang, Ying; Liu, Feifei; Ye, Bingjue; Chen, Zhi; Zheng, Min; Liu, Yanning.

Afiliação

Lou G; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yang Y; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Liu F; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ye B; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chen Z; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zheng M; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Liu Y; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

J Cell Mol Med ; 21(11): 2963-2973, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28544786

Assuntos

Tecido Adiposo/metabolismo; Cirrose Hepática/genética; Cirrose Hepática/terapia; Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais/metabolismo; MicroRNAs/genética; Tecido Adiposo/citologia; Animais; Tetracloreto de Carbono; Comunicação Celular; Ciclo Celular/genética; Diferenciação Celular; Engenharia Celular; Proliferação de Células; Ciclina G1/genética; Ciclina G1/metabolismo; Exossomos/metabolismo; Regulação da Expressão Gênica; Células Estreladas do Fígado/metabolismo; Células Estreladas do Fígado/patologia; Cirrose Hepática/induzido quimicamente; Cirrose Hepática/patologia; Células-Tronco Mesenquimais/citologia; Camundongos; Camundongos Endogâmicos C57BL; MicroRNAs/metabolismo; Cultura Primária de Células; Prolil Hidroxilases/genética; Prolil Hidroxilases/metabolismo; Receptor IGF Tipo 1/genética; Receptor IGF Tipo 1/metabolismo; Transdução de Sinais

Palavras-chave

adipose tissue-derived mesenchymal stem cells; exosome; hepatic stellate cells; liver fibrosis; miR-122

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo / MicroRNAs / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / Cirrose Hepática Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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