Systemic necrotizing polyarteritis in three weaned lambs from one flock.
J Vet Diagn Invest
; 29(5): 733-737, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28545345
Systemic necrotizing polyarteritis was diagnosed in three 7-11-mo-old lambs from the same flock. Aneurysmal dilation and rupture of the gastroduodenal artery in 1 lamb resulted in fatal hemorrhage. All lambs had severe necrotizing vasculitis involving the small intestine, abomasum, mesentery, kidney, and heart with concurrent lymphocytic enteritis. Immunohistochemistry for T- and B-lymphocytes and macrophages found a T-cell- and macrophage-dominant transmural vascular infiltrate and T-cell-associated enteritis. PCR analysis for pestivirus failed to identify infection in 1 lamb, and more extensive viral microarray techniques applied to the second and third lamb failed to detect viral nucleic acid. The identification of 3 cases within 1 flock raises the possibility of a common etiology; however, no cause was established. A genetic etiology was not considered likely as not all of the lambs were related. The presence of concurrent T-lymphocyte-associated enteritis raises the possibility of an immune-mediated disease process linking the vasculitis and enteric lesions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poliarterite Nodosa
/
Doenças dos Ovinos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article