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Inflammation and attentional bias in breast cancer survivors.
Boyle, Chloe C; Ganz, Patricia A; Van Dyk, Kathleen M; Bower, Julienne E.
Afiliação
  • Boyle CC; Department of Psychology, University of California-Los Angeles, Los Angeles, CA, United States. Electronic address: ccboyle@ucla.edu.
  • Ganz PA; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, United States; Schools of Medicine and Public Health, University of California-Los Angeles, Los Angeles, CA, United States.
  • Van Dyk KM; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, United States.
  • Bower JE; Department of Psychology, University of California-Los Angeles, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences,
Brain Behav Immun ; 66: 85-88, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28546059
Evidence suggests an association between inflammation and depression, although findings are mixed. Focusing on core processes in depression may clarify associated biological underpinnings. Negative cognitive bias is a key component of depression, but has not been examined in relation to inflammation. Thus, we tested the hypothesis that elevated inflammatory markers would be associated with negative attentional bias in a sample of 91 breast cancer survivors. Participants were drawn from a larger study and provided blood samples for assessment of peripheral markers of inflammation and completed questionnaires and neuropsychological testing. Attentional bias towards emotional stimuli was assessed with a dot-probe computer task using emotional (sad, happy, angry) and neutral faces. Circulating concentrations of C-reactive protein (CRP) were positively correlated with negative attentional bias (p=.03), such that women with higher CRP allocated greater attention towards sad faces. This association held when controlling for attention function and current depressive symptoms. While cross-sectional, results are consistent with research showing that inflammation heightens the salience of negative emotional stimuli, and identify a novel pathway through which inflammation may lead to depression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Viés de Atenção / Inflamação Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Viés de Atenção / Inflamação Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article