Degradation of proteoglycan 4/lubricin by cathepsin S: Potential mechanism for diminished ocular surface lubrication in Sjögren's syndrome.

Regmi, Suresh C; Samsom, Michael L; Heynen, Miriam L; Jay, Gregory D; Sullivan, Benjamin D; Srinivasan, Sruthi; Caffery, Barbara; Jones, Lyndon; Schmidt, Tannin A

Regmi, Suresh C; Samsom, Michael L; Heynen, Miriam L; Jay, Gregory D; Sullivan, Benjamin D; Srinivasan, Sruthi; Caffery, Barbara; Jones, Lyndon; Schmidt, Tannin A.

Afiliação

Regmi SC; Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
Samsom ML; Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada.
Heynen ML; Centre for Contact Lens Research, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada.
Jay GD; Emergency Medicine, Brown University, Providence, RI, United States.
Sullivan BD; TearLab, San Diego, CA, United States; Lµbris BioPharma LLC, Framingham, MA, United States.
Srinivasan S; Centre for Contact Lens Research, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada.
Caffery B; Toronto Eye Care, Toronto, ON, Canada.
Jones L; Centre for Contact Lens Research, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada.
Schmidt TA; Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada; Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada. Electronic address: tschmidt@ucalgary.ca.

Exp Eye Res ; 161: 1-9, 2017 08.

Article em En | MEDLINE | ID: mdl-28549901

Assuntos

Catepsinas/farmacologia; Proteoglicanas/metabolismo; Síndrome de Sjogren/tratamento farmacológico; Lágrimas/efeitos dos fármacos; Sequência de Aminoácidos; Western Blotting; Córnea/metabolismo; Relação Dose-Resposta a Droga; Eletroforese em Gel de Poliacrilamida; Fricção; Glicoproteínas/metabolismo; Humanos; Lubrificação; Dados de Sequência Molecular; Proteínas Recombinantes/metabolismo; Síndrome de Sjogren/metabolismo; Propriedades de Superfície; Espectrometria de Massas em Tandem; Lágrimas/metabolismo; Fatores de Tempo

Palavras-chave

Boundary lubrication; Cathepsin S; Dry eye; Lubricin; Proteoglycan 4; Sjögren's syndrome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteoglicanas / Lágrimas / Síndrome de Sjogren / Catepsinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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