The Expression of BTS-2 Enhances Cell Growth and Invasiveness in Renal Cell Carcinoma.
Anticancer Res
; 37(6): 2853-2860, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28551621
ABSTRACT
BACKGROUND:
Renal cell carcinoma (RCC) is one of the most common types of cancer in developed countries. Bone marrow stromal cell antigen 2 (BST2) gene, which encodes BST2 transmembrane glycoprotein, is overexpressed in several cancer types. In the present study, we analyzed the expression and function of BST2 in RCC. MATERIALS ANDMETHODS:
BST2 expression was analyzed by immunohistochemistry in 123 RCC cases. RNA interference was used to inhibit BST2 expression in a RCC cell line.RESULTS:
Immunohistochemical analysis showed that 32% of the 123 RCC cases were positive for BST2. BST2 expression was positively associated with tumour stage. Furthermore, BST2 expression was an independent predictor of survival in patients with RCC. BST2 siRNA-transfected Caki-1 cells displayed significantly reduced cell growth and invasive activity relative to negative control siRNA-transfected cells.CONCLUSION:
These results suggest that BST2 plays an important role in the progression of RCC. Because BST2 is expressed on the cell membrane, BST2 is a good therapeutic target for RCC.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Antígenos CD
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Neoplasias Renais
Limite:
Aged
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article