Pluripotent stem cells and their utility in treating photoreceptor degenerations.
Prog Brain Res
; 231: 191-223, 2017.
Article
em En
| MEDLINE
| ID: mdl-28554397
ABSTRACT
Age-related macular degeneration and inherited retinal degenerations represent the leading causes of blindness in industrialized countries. Despite different initiating causes, they share a common final pathophysiology, the loss of the light sensitive photoreceptors. Replacement by transplantation may offer a potential treatment strategy for both patient populations. The last decade has seen remarkable progress in our ability to generate retinal cell types, including photoreceptors, from a variety of murine and human pluripotent stem cell sources. Driven in large part by the requirement for renewable cell sources, stem cells have emerged not only as a promising source of replacement photoreceptors but also to provide in vitro systems with which to study retinal development and disease processes and to test therapeutic agents.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Degeneração Retiniana
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Células-Tronco Pluripotentes
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Transplante de Células-Tronco
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article