TGFß pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.

Grand Moursel, Laure; Munting, Leon P; van der Graaf, Linda M; van Duinen, Sjoerd G; Goumans, Marie-Jose T H; Ueberham, Uwe; Natté, Remco; van Buchem, Mark A; van Roon-Mom, Willeke M C; van der Weerd, Louise

Grand Moursel, Laure; Munting, Leon P; van der Graaf, Linda M; van Duinen, Sjoerd G; Goumans, Marie-Jose T H; Ueberham, Uwe; Natté, Remco; van Buchem, Mark A; van Roon-Mom, Willeke M C; van der Weerd, Louise.

Afiliação

Grand Moursel L; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Munting LP; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
van der Graaf LM; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
van Duinen SG; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Goumans MTH; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Ueberham U; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Natté R; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
van Buchem MA; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.
van Roon-Mom WMC; Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.
van der Weerd L; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

Brain Pathol ; 28(4): 495-506, 2018 07.

Article em En | MEDLINE | ID: mdl-28557134

Assuntos

Angiopatia Amiloide Cerebral Familiar/metabolismo; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Idoso; Idoso de 80 Anos ou mais; Angiopatia Amiloide Cerebral Familiar/patologia; Feminino; Lobo Frontal/irrigação sanguínea; Lobo Frontal/metabolismo; Lobo Frontal/patologia; Humanos; Masculino; Pessoa de Meia-Idade; Lobo Occipital/irrigação sanguínea; Lobo Occipital/metabolismo; Lobo Occipital/patologia; Fosforilação; Transdução de Sinais; Regulação para Cima

Palavras-chave

TGFß; amyloid ß mutation E22Q; cerebral amyloid angiopathy; hereditary cerebral hemorrhage with amyloidosis-Dutch type; phospho-SMAD2/3 granules; postmortem human brain tissue

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Angiopatia Amiloide Cerebral Familiar / Proteína Smad2 / Proteína Smad3 Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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