Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.
J Clin Oncol
; 3(3): 311-5, 1985 Mar.
Article
em En
| MEDLINE
| ID: mdl-2857774
ABSTRACT
A multidrug resistance phenotype is frequently observed in animal and human cell lines selected for in vitro resistance to a single chemotherapeutic agent. Overexpression of a highly conserved cell-surface glycoprotein (P-glycoprotein) is consistently associated with this phenotype in these mutant lines. A monoclonal antibody against P-glycoprotein was used to examine tumor samples from five patients with advanced ovarian cancer for evidence of P-glycoprotein overexpression. High levels of P-glycoprotein were detected in samples from two patients suggesting that a multidrug resistance mutation may also occur in ovarian cancer. This finding has broad implications for the understanding of nonresponse to chemotherapy in a variety of human neoplasms, and may provide a rational explanation for failure of chemotherapy in treatment of advanced ovarian cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Glicoproteínas
/
Cistadenocarcinoma
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article