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In vitro uptake and immune functionality of digested Rosemary extract delivered through food grade vehicles.
Arranz, E; Guri, A; Fornari, T; Mendiola, J A; Reglero, G; Corredig, M.
Afiliação
  • Arranz E; Department of Food Science, University of Guelph, Guelph, ON N1G 2W1, Canada. Electronic address: earranz@uoguelph.ca.
  • Guri A; Department of Food Science, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • Fornari T; Institute of Food Science Research (CIAL). Universidad Autónoma de Madrid (CEI UAM+CSIC). 28049 Madrid, Spain.
  • Mendiola JA; Laboratory of Foodomics, Institute of Food Science Research (CIAL), CSIC, 28049 Madrid, Spain.
  • Reglero G; Institute of Food Science Research (CIAL). Universidad Autónoma de Madrid (CEI UAM+CSIC). 28049 Madrid, Spain; Imdea-Food Institute, Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, Spain.
  • Corredig M; Department of Food Science, University of Guelph, Guelph, ON N1G 2W1, Canada.
Food Res Int ; 97: 71-77, 2017 07.
Article em En | MEDLINE | ID: mdl-28578067
The digestion, absorption, uptake and bioavailability of a rosemary supercritical fluid extract encapsulated in oil in water emulsion were studied. Two emulsions with opposite surface charge were prepared, containing 7% canola oil, and either 2% lactoferrin or whey protein isolate. When absorption and uptake of carnosic acid and carnosol were followed on Caco-2 cell monolayers, there were no differences with protein type. However, when co-cultures of HT-29 MTX were employed, the presence of mucus caused a higher retention of carnosic acid in the apical layer for lactoferrin emulsions. The immune activity of the bioavailable fractions collected from cell absorption experiments was tested ex vivo on murine splenocytes. Although transport through the intestinal barrier models was low, the bioavailable fractions showed a significant effect on splenocytes proliferation. These results demonstrated the potential of using rosemary supercritical extract through protein stabilized oil in water emulsions, as a food with immunomodulatory functionality.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Rosmarinus / Emulsões Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Rosmarinus / Emulsões Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article