Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome <i>b</i> That Are Transmissible through Mosquitoes.

Blake, Lynn D; Johnson, Myles E; Siegel, Sasha V; McQueen, Adonis; Iyamu, Iredia D; Shaikh, Abdul Kadar; Shultis, Michael W; Manetsch, Roman; Kyle, Dennis E

Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes.

Blake, Lynn D; Johnson, Myles E; Siegel, Sasha V; McQueen, Adonis; Iyamu, Iredia D; Shaikh, Abdul Kadar; Shultis, Michael W; Manetsch, Roman; Kyle, Dennis E.

Afiliação

Blake LD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Johnson ME; Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA.
Siegel SV; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
McQueen A; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Iyamu ID; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Shaikh AK; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Shultis MW; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Manetsch R; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Kyle DE; Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, USA.

Antimicrob Agents Chemother ; 61(8)2017 08.

Article em En | MEDLINE | ID: mdl-28584157

Assuntos

Anopheles/parasitologia; Antimaláricos/farmacologia; Atovaquona/farmacologia; Citocromos b/genética; Resistência a Medicamentos/genética; Naftoquinonas/farmacologia; Plasmodium berghei/genética; Plasmodium falciparum/genética; Animais; DNA de Protozoário/genética; Feminino; Malária Falciparum/tratamento farmacológico; Malária Falciparum/parasitologia; Malária Falciparum/transmissão; Camundongos; Camundongos Endogâmicos BALB C; Mutação/genética; Plasmodium berghei/efeitos dos fármacos; Plasmodium falciparum/efeitos dos fármacos

Palavras-chave

antimalarial agents; drug resistance mechanisms; menoctone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium berghei / Plasmodium falciparum / Resistência a Medicamentos / Naftoquinonas / Citocromos b / Atovaquona / Anopheles / Antimaláricos Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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