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Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition.
Warrier, V; Grasby, K L; Uzefovsky, F; Toro, R; Smith, P; Chakrabarti, B; Khadake, J; Mawbey-Adamson, E; Litterman, N; Hottenga, J-J; Lubke, G; Boomsma, D I; Martin, N G; Hatemi, P K; Medland, S E; Hinds, D A; Bourgeron, T; Baron-Cohen, S.
Afiliação
  • Warrier V; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.
  • Grasby KL; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Uzefovsky F; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.
  • Toro R; Department of Psychology, Ben Gurion University of the Negev, Be'er Sheva, Israel.
  • Smith P; CNRS UMR 3571: Genes, Synapses and Cognition, Institut Pasteur, Paris, France.
  • Chakrabarti B; Université Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France.
  • Khadake J; Institut Pasteur, Paris, France.
  • Mawbey-Adamson E; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.
  • Litterman N; Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
  • Hottenga JJ; NIHR Cambridge BioResource, Cambridge University and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Lubke G; NIHR Cambridge BioResource, Cambridge University and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Boomsma DI; 23andMe Inc., Mountain View, CA, USA.
  • Martin NG; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Hatemi PK; EMGO+ Institute for Health and Care Research, VU Medical Center, Amsterdam, The Netherlands.
  • Medland SE; Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Hinds DA; Department of Psychology, University of Notre Dame, South Bend, IN, USA.
  • Bourgeron T; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Baron-Cohen S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Mol Psychiatry ; 23(6): 1402-1409, 2018 06.
Article em En | MEDLINE | ID: mdl-28584286
ABSTRACT
We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10-16), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, Pmeta=1.58 × 10-8). Common single nucleotide polymorphisms explained 5.8% (95% CI 4.5%-7.2%; P=1.00 × 10-17) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Empatia Tipo de estudo: Diagnostic_studies / Prognostic_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Empatia Tipo de estudo: Diagnostic_studies / Prognostic_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article