Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds.
Metallomics
; 9(7): 824-839, 2017 07 19.
Article
em En
| MEDLINE
| ID: mdl-28594012
ABSTRACT
Bacteria often produce siderophores to facilitate iron uptake. One of the most studied siderophores is enterobactin, the macrolactone trimer of 2,3-dihydroxybenzoyl-l-serine, produced by E. coli and many other enteric bacteria. Other siderophores are variants of enterobactin, with structural modifications including expansion of the tri-serine core to a tetra-serine macrolactone, substitution of l-serine with l-threonine, insertion of amino acids (i.e., Gly, l-Ala, d-Lys, d- and l-Arg, l-Orn), catechol glucosylation, and linearization of the tri-serine macrolactone core. In this review we summarize the current understanding of the biosyntheses of these enterobactin variants, placing them in contrast with the well-established biosynthesis of enterobactin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Serina
/
Treonina
/
Catecóis
/
Sideróforos
/
Lactonas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article