Comparative morphology and phagocytic capacity of primary human adult microglia with time-lapse imaging.
J Neuroimmunol
; 310: 143-149, 2017 09 15.
Article
em En
| MEDLINE
| ID: mdl-28606377
ABSTRACT
Microglia provide immune surveillance within the brain and spinal cord. Various microglial morphologies include ramified, amoeboid, and pseudopodic. The link between form and function is not clear, especially for human adult microglia which are limited in availability for study. Here, we examined primary human microglia isolated from normal-appearing white matter. Pseudopodic and amoeboid microglia were effective phagocytes, taking up E. coli bioparticles using ruffled cell membrane sheets and retrograde transport. Pseudopodic and amoeboid microglia were more effective phagocytes as compared to ramified microglia or monocyte-derived dendritic cells. Thus, amoeboid and pseudopodic microglia may both be effective as brain scavengers.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fagócitos
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Microglia
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Imagem com Lapso de Tempo
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Amoeba
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article