Genetics of Depression: Progress at Last.
Curr Psychiatry Rep
; 19(8): 43, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28608123
ABSTRACT
PURPOSE OF REVIEW We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size. RECENT FINDINGS:
The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Herança Multifatorial
/
População Branca
/
Depressão
/
Transtorno Depressivo Maior
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article