Comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin-induced diabetic rats.

BACKGROUND: Diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both. Daily consumption of probiotics, particularly Lactobacilli, has been proposed as a new strategy for prevention or control of diabetes. METHODS: In the current study, the effects of various probiotics including Lactobacillus reuteri (L reuteri), Lactobacillus crispatus (L crispatus), and Bacillus subtilis on the levels of blood glucose, lipid, and insulin as well as haemoglobin A1c (HbA1c ) were investigated in rat models of streptozotocin (STZ)-induced diabetes and compared with metformin. In addition, GLUT-4 and PPAR-γ transcript levels have been analysed in adipose tissues. RESULTS: A significant decrease in plasma glucose and HbA1c levels and a dramatic increase in insulin levels have been detected after consumption of probiotics. Furthermore, lipid profiles have been improved. The expression of Glut-4 and Ppar-γ genes in adipose tissues also increased after treatment period. CONCLUSION: The results of this experiment showed that daily consumption of probiotics can be effective in control of STZ-induced diabetes and its complications.