Fluorine-18 labelled building blocks for PET tracer synthesis.
Chem Soc Rev
; 46(15): 4709-4773, 2017 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-28608906
ABSTRACT
Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 labelled PET tracers. These PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in the last step of the synthesis, or by a building block approach (also called modular build-up approach), introducing fluorine-18 in a fast and efficient manner in a building block, which is reacted further in one or multiple reaction steps to form the PET tracer. This review presents a comprehensive overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.
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1
Base de dados:
MEDLINE
Assunto principal:
Compostos Radiofarmacêuticos
/
Tomografia por Emissão de Pósitrons
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article