[Pharmacokinetics of Curcumin Ethosomes in Rats in vitro].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 48(2): 290-294, 2017 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-28612545
ABSTRACT
OBJECTIVES:
To study the oral phamacokinetics of curcumin ethosomes in rats.METHODS:
Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of curcumin ethosomes in rats.RESULTS:
Analyzed by non-compartmental method, the area under concentration-time curve from 0 to last time [AUC(0-72h)] of curcumin ethosomes was 1.6 times larger than that of free curcumin, the peak concentration (C max) of curcumin ethosomes was 1.5 times higher than that of free curcumin, the relative bioavailability of curcumin ethosomes was 152.2%. The 90% confidential interval of AUC(0-72 h)was 102.2%-128.5%, which was not in standard interval of bioequialence. Analyzed by compartmental method, the AUC(0-72 h)of curcumin ethosomes was 1.4 times larger than that of free curcumin and the relative bioavailability of curcumin ethosomes was 128.2%.CONCLUSION:
The curcumin ethosomes can enhance bioavailability, which has a bioinequivalence with free curcumin.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Curcumina
/
Lipossomos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article