A nitrile-stabilized ammonium ylide as a masked C-C[double bond, length as m-dash]N synthon in heterocyclization with amidine-imine: 3-component assembly to fused pyrimidine scaffolds.
Chem Commun (Camb)
; 53(51): 6941-6944, 2017 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-28612882
ABSTRACT
A unique reactivity of a nitrile-stabilized quaternary ammonium ylide as a masked C-C[double bond, length as m-dash]N synthon in contrast to its usual sigmatropic rearrangement has been demonstrated. Its reaction with 2-aminopyridine-derived aldimine undergoes electronically-assisted nucleophilic additions and Hofmann elimination, and provides a new method to access fused pyrimidines.
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MEDLINE
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En
Ano de publicação:
2017
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Article