The UPRER: Sensor and Coordinator of Organismal Homeostasis.
Mol Cell
; 66(6): 761-771, 2017 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-28622521
ABSTRACT
Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and respond to proteotoxic perturbations, cells have evolved compartment-specific stress responses, such as the unfolded protein response of the endoplasmic reticulum (UPRER). However, UPRER function is impaired with age, which, we propose, creates a permissive environment for protein aggregation, unresolved ER stress, and chronic inflammation. Understanding age-related changes to the UPRER will provide new avenues for therapeutic intervention in metabolic disease, neurodegeneration, and aging.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Retículo Endoplasmático
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Resposta a Proteínas não Dobradas
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Estresse do Retículo Endoplasmático
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article