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Challenges in longitudinal exposure-response modeling of data from complex study designs: a case study of modeling CDAI score for ustekinumab in patients with Crohn's disease.
Hu, Chuanpu; Adedokun, Omoniyi J; Chen, Yang; Szapary, Philippe O; Gasink, Christopher; Sharma, Amarnath; Zhou, Honghui.
Afiliação
  • Hu C; Global Clinical Pharmacology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. CHu25@its.jnj.com.
  • Adedokun OJ; Global Clinical Pharmacology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA.
  • Chen Y; Global Clinical Pharmacology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA.
  • Szapary PO; Clinical Immunology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA.
  • Gasink C; Clinical Immunology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA.
  • Sharma A; Global Clinical Pharmacology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA.
  • Zhou H; Global Clinical Pharmacology, Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA.
J Pharmacokinet Pharmacodyn ; 44(5): 425-436, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28623612
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Doença de Crohn / Relação Dose-Resposta a Droga / Ustekinumab / Modelos Biológicos Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Doença de Crohn / Relação Dose-Resposta a Droga / Ustekinumab / Modelos Biológicos Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article