Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies.
Nutrients
; 9(6)2017 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-28629150
ABSTRACT
BACKGROUND:
Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity.AIM:
To analyze and report the outcome of experimental animal studies on the protective effects of NS/TQ on chemotherapy-associated kidney complications.DESIGN:
Standard systematic review and narrative synthesis. DATA SOURCES MEDLINE, EMBASE databases were searched for relevant articles published up to March 2017. Additionally, a manual search was performed. Criteria for a study's inclusion were conducted in animals, systematic reviews and meta-analysis, containing data on nephroprotective effects of NS/TQ compared to a placebo or other substance. All strains and genders were included.RESULTS:
The database search yielded 71 studies, of which 12 (cisplatin-induced nephrotoxicity 8; methotrexate-induced nephrotoxicity 1; doxorubicin-induced nephrotoxicity 2; ifosfamide-induced nephrotoxicity 1) were included in this review.CONCLUSIONS:
Experimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation and increasing activity of antioxidant enzymes in renal tissue of chemotherapy-treated animals.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nigella sativa
/
Benzoquinonas
/
Nefropatias
/
Antineoplásicos
Tipo de estudo:
Systematic_reviews
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article