Composite lymphoma with coexistence of diffuse large B-cell lymphoma and anaplastic large cell lymphoma: Diagnostic pitfalls.
Indian J Pathol Microbiol
; 60(2): 275-278, 2017.
Article
em En
| MEDLINE
| ID: mdl-28631654
ABSTRACT
Composite lymphoma is a rare tumor composed of two or more distinct lymphomas in the same topographic site or tissue. Several combinations of B-cell non-Hodgkin lymphoma (NHL), T-cell NHL, and Hodgkin lymphoma can occur with different prognoses and treatments. The coexistence of a B-cell NHL and a T-cell NHL is unusual. The exact etiology of composite lymphoma is unknown; however, few mechanisms have been proposed to explain its pathogenesis. The chemotherapeutic protocols are heterogeneous but are essentially targeted against the high-grade component. Most of the cases show worse outcome with a median survival of 12 months. In this article, we report a case of composite lymphoma which was initially diagnosed as diffuse large B-cell lymphoma, and the presence of CD3-positive atypical cells in the bone marrow urged us to re-evaluate the lymph node biopsy following which a focus of Alk-1-positive anaplastic large cell lymphoma was identified.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfoma de Células B
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Linfoma Difuso de Grandes Células B
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Linfoma Anaplásico de Células Grandes
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Linfoma Composto
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Humans
/
Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article