t-BuOK-mediated reductive addition of P(O)-H compounds to terminal alkynes forming ß-arylphosphine oxides.
Org Biomol Chem
; 15(26): 5462-5467, 2017 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-28632274
ABSTRACT
A novel and efficient t-BuOK-mediated reductive addition of P(O)-H compounds to terminal alkynes was developed. A variety of ß-arylphosphine oxides including the valuable ß-heteroarylphosphine oxides were produced in moderate to high yields under mild reaction conditions. This reaction may proceed via a tandem process involving regio-selective double addition and subsequent transfer hydrogenation.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
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Article