Effects of metoclopramide on detrusor function.
J Urol
; 134(4): 791-4, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-2863396
ABSTRACT
Metoclopramide (Reglan) has been widely used as a motility agent because of its contractile effects on gastrointestinal smooth muscle. This agent also may demonstrate significant effects in the urinary system; however, controlled studies of possible effects on bladder function have not been previously reported. Metoclopramide effects on the detrusor smooth muscle were studied using a canine model system. Metoclopramide was compared with bethanechol chloride and a control substance in a random double blind study. Preliminary data from this animal model suggests that metoclopramide significantly increased detrusor contractility as manifested by a decrease in bladder capacity, an increase in detrusor peak voiding pressure and a decrease in post-void residual volume. These effects were similar to those manifested by parenteral bethanechol chloride.
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Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Metoclopramida
/
Contração Muscular
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article