Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2: syntheses of CF2H-containing spirooxindoles.
Org Biomol Chem
; 15(26): 5571-5578, 2017 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-28639676
ABSTRACT
An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2 for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF2H group and three contiguous stereogenic centers in up to 84% yield and 99 1 trans/cis.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
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Article