Subversion of RAB5-regulated autophagy by the intracellular pathogen Ehrlichia chaffeensis.
Small GTPases
; 10(5): 343-349, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-28650718
ABSTRACT
Intracellular pathogens often exploit RAB functions to establish a safe haven in which to survive and proliferate. Ehrlichia chaffeensis, an obligatory intracellular bacterium, resides in specialized membrane-bound inclusions that have early endosome-like characteristics, e.g., resident RAB5 GTPase and RAB5 effectors, including VPS34 (the catalytic subunit of class III phosphatidylinositol 3-kinase), but the inclusions lack late endosomal or lysosomal markers. Within inclusions, Ehrlichia obtains host-derived nutrients by inducing RAB5-regulated autophagy using Ehrlichia translocated factor-1 deployed by its type IV secretion system. This manipulation of RAB5 by a bacterial molecule offers a simple strategy for Ehrlichia to avoid destruction in lysosomes and obtain nutrients, membrane components, and a homeostatic intra-host-cell environment in which to grow.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ehrlichiose
/
Ehrlichia chaffeensis
/
Proteínas rab5 de Ligação ao GTP
/
Sistemas de Secreção Tipo IV
/
Morte Celular Autofágica
/
Interações Hospedeiro-Parasita
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article