Assessment of amyloid ß in pathologically confirmed frontotemporal dementia syndromes.
Alzheimers Dement (Amst)
; 9: 10-20, 2017.
Article
em En
| MEDLINE
| ID: mdl-28653036
ABSTRACT
INTRODUCTION:
The diagnostic utility of in vivo amyloid ß (Aß) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aß in pathologically confirmed FTD syndromes.METHODS:
Aß was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of 11C-Pittsburgh compound B (PiB)-positron emission tomography imaging was assessed in a subset of FTD cases (n = 15).RESULTS:
Aß was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aß with PiB standard uptake value ratio scaled to the white matter.DISCUSSION:
The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.
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Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article