Evoked and event-related potentials in disorders of consciousness: A quantitative review.
Conscious Cogn
; 54: 155-167, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-28663011
ABSTRACT
Sixty-one publications about evoked and event-related potentials (EP and ERP, respectively) in patients with severe Disorders of Consciousness (DoC) were found and analyzed from a quantitative point of view. Most studies are strongly underpowered, resulting in very broad confidence intervals (CI). Results of such studies cannot be correctly interpreted, because, for example, CI>1 (in terms of Cohen's d) indicate that the real effect may be very strong, very weak, or even opposite to the reported effect. Furthermore, strong negative correlations were obtained between sample size and effect size, indicating a possible publication bias. These correlations characterized not only the total data set, but also each thematically selected subset. The minimal criteria of a strong study to EP/ERP in DoC are proposed at least 25 patients in each patient group; as reliable diagnosis as possible; the complete report of all methodological details and all details of results (including negative results); and the use of appropriate methods of data analysis. Only three of the detected 60 studies (5%) satisfy these criteria. The limitations of the current approach are also discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Consciência
/
Potenciais Evocados
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article