Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children.
Environ Health Perspect
; 125(6): 067007, 2017 06 16.
Article
em En
| MEDLINE
| ID: mdl-28669936
ABSTRACT
BACKGROUND:
Long-term exposure to ambient air pollution can lead to adverse health effects in children; however, underlying biological mechanisms are not fully understood.OBJECTIVES:
We evaluated the effect of air pollution exposure during different time periods on mRNA expression as well as circulating levels of inflammatory cytokines in children.METHODS:
We measured a panel of 10 inflammatory markers in peripheral blood samples from 670 8-y-old children in the Barn/Child, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) birth cohort. Outdoor concentrations of nitrogen dioxide (NO2) and particulate matter (PM) with aerodynamic diameter <10 µm (PM10) from road traffic were estimated for residential, daycare, and school addresses using dispersion modeling. Time-weighted average exposures during infancy and at biosampling were linked to serum cytokine levels using linear regression analysis. Furthermore, gene expression data from 16-year-olds in BAMSE (n=238) were used to evaluate links between air pollution exposure and expression of genes coding for the studied inflammatory markers.RESULTS:
A 10 µg/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI) 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. However, no clear associations were observed for current exposure. Results were similar using PM10, which showed a high correlation with NO2. The functional analysis identified several differentially expressed genes in response to air pollution exposure during infancy, including IL10, IL13, and TNF;.CONCLUSION:
Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https//doi.org/10.1289/EHP460.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Emissões de Veículos
/
Citocinas
/
Poluição do Ar
/
Exposição Ambiental
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article