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Polymorphisms in immune-inflammatory response genes and the risk of deficit schizophrenia.
Mak, Monika; Misiak, Blazej; Frydecka, Dorota; Pelka-Wysiecka, Justyna; Kucharska-Mazur, Jolanta; Samochowiec, Agnieszka; Bienkowski, Przemyslaw; Pawlak-Adamska, Edyta; Karabon, Lidia; Szmida, Elzbieta; Skiba, Pawel; Kotowicz, Kamila; Piotrowski, Patryk; Beszlej, Jan Aleksander; Samochowiec, Jerzy.
Afiliação
  • Mak M; Department of Psychiatry, Pomeranian Medical University, 26 Broniewski Street, 71-460 Szczecin, Poland.
  • Misiak B; Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland. Electronic address: mblazej@interia.eu.
  • Frydecka D; Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
  • Pelka-Wysiecka J; Department of Psychiatry, Pomeranian Medical University, 26 Broniewski Street, 71-460 Szczecin, Poland.
  • Kucharska-Mazur J; Department of Psychiatry, Pomeranian Medical University, 26 Broniewski Street, 71-460 Szczecin, Poland.
  • Samochowiec A; Institute of Psychology, Department of Clinical Psychology, University of Szczecin, 69 Krakowska Street, 71-017 Szczecin, Poland.
  • Bienkowski P; Department of Psychiatry, Medical University of Warsaw, 27 Nowowiejska Street, 00-665 Warsaw, Poland.
  • Pawlak-Adamska E; Department of Experimental Therapy, Laboratory of Immunopathology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla Street, 51-114 Wroclaw, Poland.
  • Karabon L; Department of Experimental Therapy, Laboratory of Immunopathology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla Street, 51-114 Wroclaw, Poland.
  • Szmida E; Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
  • Skiba P; Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.
  • Kotowicz K; Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
  • Piotrowski P; Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
  • Beszlej JA; Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
  • Samochowiec J; Department of Psychiatry, Pomeranian Medical University, 26 Broniewski Street, 71-460 Szczecin, Poland.
Schizophr Res ; 193: 359-363, 2018 03.
Article em En | MEDLINE | ID: mdl-28673752
ABSTRACT
Polymorphisms in immune-inflammatory response genes are believed to impact schizophrenia susceptibility. However, it remains unknown whether immunogenetic factors play a role in the etiology of deficit schizophrenia (D-SCZ). Therefore, we genotyped four polymorphisms in genes encoding two immune system regulatory proteins (CTLA-4 rs231775 and CD28 rs3116496), interleukin-6 (IL6 rs1800795) and transforming growth factor-ß (TGFB1 rs1800470) in 513 schizophrenia patients and 374 controls. The CD28 rs3116496-CC genotype and C-allele were significantly more frequent in the whole group of patients and D-SCZ patients compared to controls. Our results indicate that the CD28 rs3116496 polymorphism might impact the risk of schizophrenia, especially D-SCZ.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Citocinas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Citocinas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article