Homoisoflavanones with estrogenic activity from the rhizomes of Polygonatum sibiricum.
J Asian Nat Prod Res
; 20(1): 92-100, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28675939
ABSTRACT
A new homoisoflavanone, (3R)-5-hydroxy-7-methoxyl-3-(2'-hydroxy-4'- methoxybenzyl)-chroman-4-one (1), together with six known analogs, were isolated from the rhizomes of Polygonatum sibiricum. Their structures were elucidated on the basis of extensive spectroscopic analysis. All compounds were tested for their estrogenic activity using the MCF-7 estrogenresponsive human breast cancer cell lines. At a dose of 0.1 µmol/L, compounds 1-7 exhibited significant proliferative effects on MCF-7 cells compared with E2. The molecular docking study results indicated that the activity of compounds 3, 5, 6, and 7 may be the binding with ERR.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
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Rizoma
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Polygonatum
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Estrogênios
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article