The Management of Dyslipidaemia in Patients with Type 2 Diabetes Mellitus Receiving Lipid-Lowering Drugs: A Sub-Analysis of the CEPHEUS Findings.
Curr Vasc Pharmacol
; 16(4): 368-375, 2018.
Article
em En
| MEDLINE
| ID: mdl-28677510
ABSTRACT
BACKGROUND:
Dyslipidaemia is a risk factor for macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Our aim was to assess the use of lipid lowering drugs (LLDs) in patients with T2DM and co-existing dyslipidaemia.METHOD:
A multicentre, non-interventional survey conducted in 6 Middle Eastern countries (Bahrain, Oman, Qatar, United Arab Emirates, Kingdom of Saudi Arabia and Kuwait). Patients with T2DM (n = 3338) taking LLD treatment for ≥3 months with no dose change for ≥6 weeks were enrolled.RESULTS:
The mean age (SD) of T2DM patients was 56.6 ±10.6 years; the majority (99%) were on statin monotherapy. Only 48% of these patients achieved their low density lipoprotein cholesterol (LDL-C) goal and 67.7% of the patients had a high cardiovascular disease (CVD) risk according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines. Of those who achieved LDL-C goals (n=1589), approximately one-third were at very high CVD risk and the patients who had received statin monotherapy showed the highest proportion in LDL-C goal attainment, followed by those treated with fibrate monotherapy. In a multivariate logistic regression model, taking drugs daily (odds ratio, OR 1.64, 95% CI 1.25, 2.15) and older age (OR 1.09, 95% CI 1.01, 1.18) were significantly associated with better odds of attaining LDL-C target. In contrast, patients with higher levels of ApoA1 (OR 0.73, 95% CI [0.67,0.79]), Metabolic Syndrome (OR 0.64, 95% CI [0.53, 0.76]), higher CV risk (OR 0.33, 95% CI 0.27, 0.41), those who forgot to take their medication (OR 0.74, 95% CI 0.62,0.88) and those who stopped taking medication when cholesterol became normal (OR 0.67, 95% CI 0.55,0.82) were significantly associated with lower odds of attaining LDL-C target.CONCLUSION:
The results of this study highlight the suboptimal management of dyslipidaemia in T2DM patients at high and very high risk of CVD.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Diabetes Mellitus Tipo 2
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Dislipidemias
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LDL-Colesterol
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Hipolipemiantes
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
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Etiology_studies
/
Guideline
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Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article