An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection.

Golden, Joseph W; Beitzel, Brett; Ladner, Jason T; Mucker, Eric M; Kwilas, Steven A; Palacios, Gustavo; Hooper, Jay W

Golden, Joseph W; Beitzel, Brett; Ladner, Jason T; Mucker, Eric M; Kwilas, Steven A; Palacios, Gustavo; Hooper, Jay W.

Afiliação

Golden JW; Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States. joseph.w.golden.ctr@mail.mil.
Beitzel B; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States.
Ladner JT; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States.
Mucker EM; Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States.
Kwilas SA; Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States.
Palacios G; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States.
Hooper JW; Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States.

Sci Rep ; 7(1): 4679, 2017 07 05.

Article em En | MEDLINE | ID: mdl-28680057

Assuntos

Infecções por Arenaviridae/prevenção & controle; Arenavirus do Novo Mundo/patogenicidade; DNA Intergênico; Análise de Sequência de RNA/métodos; Vacinas Atenuadas/genética; Animais; Arenavirus do Novo Mundo/genética; Arenavirus do Novo Mundo/isolamento & purificação; Linhagem Celular; Chlorocebus aethiops; Modelos Animais de Doenças; Feminino; Cobaias; Células Endoteliais da Veia Umbilical Humana; Humanos; Mutação Puntual; RNA Viral/genética; Deleção de Sequência; Vacinas Atenuadas/isolamento & purificação; Células Vero; Fatores de Virulência/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Atenuadas / Análise de Sequência de RNA / Arenavirus do Novo Mundo / Infecções por Arenaviridae / DNA Intergênico Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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