Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma.

Lee, Byung Soo; Park, Dong Il; Lee, Da Hye; Lee, Jeong Eun; Yeo, Min-Kyung; Park, Yeon Hee; Lim, Dae Sik; Choi, Wonyoung; Lee, Da Hye; Yoo, Geon; Kim, Han-Byul; Kang, Dahyun; Moon, Jae Young; Jung, Sung Soo; Kim, Ju Ock; Cho, Sang Yeon; Park, Hee Sun; Chung, Chaeuk

Lee, Byung Soo; Park, Dong Il; Lee, Da Hye; Lee, Jeong Eun; Yeo, Min-Kyung; Park, Yeon Hee; Lim, Dae Sik; Choi, Wonyoung; Lee, Da Hye; Yoo, Geon; Kim, Han-Byul; Kang, Dahyun; Moon, Jae Young; Jung, Sung Soo; Kim, Ju Ock; Cho, Sang Yeon; Park, Hee Sun; Chung, Chaeuk.

Afiliação

Lee BS; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Park DI; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Lee DH; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Lee JE; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Yeo MK; Department of Pathology, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Park YH; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Lim DS; National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.
Choi W; National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.
Lee DH; National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.
Yoo G; National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.
Kim HB; National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.
Kang D; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Moon JY; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Jung SS; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Kim JO; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.
Cho SY; Chungnam National University School of Medicine, Daejeon, South Korea. Electronic address: nprc26@gmail.com.
Park HS; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea. Electronic address: liansalt@daum.net.
Chung C; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea. Electronic address: universe7903@gmail.com.

Biochem Biophys Res Commun ; 491(2): 493-499, 2017 09 16.

Article em En | MEDLINE | ID: mdl-28684311

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/genética; Antígeno B7-H1/genética; Receptores ErbB/genética; Regulação Neoplásica da Expressão Gênica; Fosfoproteínas/genética; RNA Mensageiro/genética; Mucosa Respiratória/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Antineoplásicos/farmacologia; Antígeno B7-H1/antagonistas & inibidores; Antígeno B7-H1/metabolismo; Sítios de Ligação; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Resistencia a Medicamentos Antineoplásicos/genética; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/metabolismo; Gefitinibe; Humanos; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Fosfoproteínas/antagonistas & inibidores; Fosfoproteínas/metabolismo; Regiões Promotoras Genéticas; Ligação Proteica; Inibidores de Proteínas Quinases/farmacologia; Quinazolinas/farmacologia; RNA Mensageiro/antagonistas & inibidores; RNA Mensageiro/metabolismo; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Mucosa Respiratória/efeitos dos fármacos; Mucosa Respiratória/patologia; Transdução de Sinais; Fatores de Transcrição de Domínio TEA; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Proteínas de Sinalização YAP

Palavras-chave

Adenocarcinoma; EGFR; Immunotherapy; PD-L1; YAP1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / RNA Mensageiro / Regulação Neoplásica da Expressão Gênica / Mucosa Respiratória / Proteínas Adaptadoras de Transdução de Sinal / Antígeno B7-H1 / Receptores ErbB Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google