Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy.
BMC Infect Dis
; 17(1): 478, 2017 07 07.
Article
em En
| MEDLINE
| ID: mdl-28687071
ABSTRACT
BACKGROUND:
Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or malignant diseases. The disease can present in three ways cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively. CASE PRESENTATION The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis. She underwent bone marrow biopsy to explore thrombocytopenia. Diagnosis of visceral leishmaniasis was made by identification of Leishman Donovan (LD) bodies in macrophages. Treatment with liposomal amphotericin B was successful. She later developed cutaneous leishmaniasis treated with amphotericin B lipid complex. She next presented with relapsing cutaneous lesions followed by rapidly progressing lymphadenopathies. Biopsy confirmed the diagnosis of leishmaniasis. Treatments by miltefosine, amphotericin B, N-methyl-glucamine antimoniate were subsequently initiated. She later presented a recurrent bone marrow involvement treated with intramuscular paromomycin and miltefosine. She died two years later from leukemia. At the time of death, she presented with a mucosal destruction of the nose. A Leishmania-specific PCR (Polymerase Chain Reaction) identified L. infantum as etiological agent.CONCLUSIONS:
Clinicians should be aware of the potential concomitant or sequential involvement of multiple anatomic localizations of Leishmania in immunosuppressed patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leishmaniose Cutânea
/
Leishmaniose Visceral
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article