Flavonoid glycosides from Barringtonia acutangula.
Bioorg Med Chem Lett
; 27(16): 3776-3781, 2017 08 15.
Article
em En
| MEDLINE
| ID: mdl-28688956
ABSTRACT
Using various chromatographic separation techniques, ten flavonoid glycosides, including six new compounds namely barringosides A-F (1-6), were isolated from a methanol extract of the Barringtonia acutangula leaves. The structure elucidation was confirmed by spectroscopic analyses, including 1D and 2D NMR, and HR ESI MS. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were also evaluated. Among the isolated compounds, quercetin 3-O-ß-d-(6-p-hydroxybenzoyl)galactopyranoside (9) showed significant effect with an IC50 of 20.00±1.68µM. This is the first report of these flavonoid glycosides from Barringtonia genus and their inhibition on LPS-induced NO production in RAW264.7 cells was reported here for the first time.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Lipopolissacarídeos
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Barringtonia
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Glicosídeos
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article