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Biodegradable nanoparticles for improved kidney bioavailability of rhein: preparation, characterization, plasma, and kidney pharmacokinetics.
Wei, Yinghui; Luo, Xiaoting; Guan, Jiani; Ma, Jianping; Zhong, Yicong; Luo, Jingwen; Li, Fanzhu.
Afiliação
  • Wei Y; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
  • Luo X; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
  • Guan J; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
  • Ma J; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
  • Zhong Y; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
  • Luo J; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
  • Li F; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou , China.
Drug Dev Ind Pharm ; 43(11): 1885-1891, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28692315
The aim of this work is to develop biodegradable nanoparticles for improved kidney bioavailability of rhein (RH). RH-loaded nanoparticles were prepared using an emulsification solvent evaporation method and fully characterized by several techniques. Kidney pharmacokinetics was assessed by implanting a microdialysis probe in rat's kidney cortex. Blood samples were simultaneously collected (via femoral artery) for assessing plasma pharmacokinetics. Optimized nanoparticles were small, with a mean particle size of 132.6 ± 5.95 nm, and homogeneously dispersed. The charge on the particles was nearly zero, the encapsulation efficiency was 62.71 ± 3.02%, and the drug loading was 1.56 ± 0.15%. In vitro release of RH from the nanoparticles showed an initial burst release followed by a sustained release. Plasma and kidney pharmacokinetics showed that encapsulation of RH into nanoparticles significantly increased its kidney bioavailability (AUCkidney/AUCplasma = 0.586 ± 0.072), clearly indicating that nanoparticles are a promising strategy for kidney drug delivery.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antraquinonas / Sistemas de Liberação de Medicamentos / Nanopartículas / Rim Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antraquinonas / Sistemas de Liberação de Medicamentos / Nanopartículas / Rim Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article