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The Role of Ghrelin and Ghrelin Signaling in Aging.
Amitani, Marie; Amitani, Haruka; Cheng, Kai-Chun; Kairupan, Timothy Sean; Sameshima, Nanami; Shimoshikiryo, Ippei; Mizuma, Kimiko; Rokot, Natasya Trivena; Nerome, Yasuhito; Owaki, Tetsuhiro; Asakawa, Akihiro; Inui, Akio.
Afiliação
  • Amitani M; Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890-8544, Japan. marisame@m3.kufm.kagoshima-u.ac.jp.
  • Amitani H; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. marisame@m3.kufm.kagoshima-u.ac.jp.
  • Cheng KC; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. amitani@m3.kufm.kagoshima-u.ac.jp.
  • Kairupan TS; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. satatonma@gmail.com.
  • Sameshima N; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. timothykairupan@gmail.com.
  • Shimoshikiryo I; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. samenana@m3.kufm.kagoshima-u.ac.jp.
  • Mizuma K; Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. ippei.35sh@gmail.com.
  • Rokot NT; Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890-8544, Japan. macchi0625@gmail.com.
  • Nerome Y; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. natasyarokot@gmail.com.
  • Owaki T; Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890-8544, Japan. neromekufm@gmail.com.
  • Asakawa A; Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890-8544, Japan. towaki@m2.kufm.kagoshima-u.ac.jp.
  • Inui A; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. asakawa@m2.kufm.kagoshima-u.ac.jp.
Int J Mol Sci ; 18(7)2017 Jul 12.
Article em En | MEDLINE | ID: mdl-28704966
ABSTRACT
With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Grelina Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Grelina Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article