The effect of glucose and free fatty acids on growth hormone (GH)-releasing factor-mediated GH secretion in rats.
Endocrinology
; 118(6): 2390-4, 1986 Jun.
Article
em En
| MEDLINE
| ID: mdl-2870916
ABSTRACT
We have examined the effect of glucose and FFA on GH-releasing factor (GHRF)-mediated GH secretion in rats under pentobarbital anesthesia. Hyperglycemia did not affect GH secretion induced by administration of 20, 100, and 200 ng GHRF/100 g body weight. In contrast, GH response to 50 ng GHRF/100 g body weight in lipid heparin-treated rats, which showed high plasma FFA levels, was significantly suppressed compared with the control group (plasma peak GH control, 1526 +/- 263 ng/ml; lipid-heparin group, 377 +/- 69 ng/ml P less than 0.05, mean +/- SEM). This suppressive effect of FFA on GH secretion was abolished by pretreatment with antisomatostatin serum (ASS) (GH level at 4 min after GHRF administration ASS-saline group, 1606 +/- 210 ng/ml; ASS-lipid-heparin group, 1531 +/- 174 ng/ml; mean +/- SEM). These results suggest that hyperglycemia does not change the GH response to GHRF and that elevation of plasma FFA suppresses GHRF-induced GH secretion by the stimulation of somatostatin secretion in rats.
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Base de dados:
MEDLINE
Assunto principal:
Hormônio do Crescimento
/
Hormônio Liberador de Hormônio do Crescimento
/
Ácidos Graxos não Esterificados
/
Glucose
Limite:
Animals
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article