Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas.
J Am Acad Dermatol
; 77(2): 333-340.e1, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28711085
ABSTRACT
BACKGROUND:
Positive or equivocal margins after wide local excision (WLE) complicate surgical management of cutaneous melanoma.OBJECTIVE:
To identify the frequency of and risk factors for positive or equivocal margins after WLE of cutaneous melanoma.METHODS:
Retrospective, single-center, cross-sectional study of 1345 consecutive melanomas treated with WLE.RESULTS:
The overall frequency of positive or equivocal margins was 4.2% (56/1345), ranging from 2.2% to 22.6%, depending on the size of the surgical margins, patient characteristics, biopsy history, and the clinicopathology of the melanoma. In descending order, independent risk factors associated with the greatest odds for positive or equivocal margins after multivariate analysis were noncompliance with recommended surgical margins (odds ratio [OR] 5.57, P = .002); anatomic location on the head, neck, hands, feet, genitals, or pretibial leg (OR 5.07, P < .001); histologic regression (OR 2.78, P = .007); in situ melanoma (OR 2.27, P = .011); multiple biopsies at the tumor site before WLE (OR 1.92 [per biopsy], P = .004); and increasing age (OR 1.049 [per year], P < .001).LIMITATIONS:
This was a single-site, retrospective observational study.CONCLUSIONS:
Clinicopathologic factors, especially location in cosmetically or functionally sensitive areas and noncompliance with recommended surgical margins, identified melanomas at increased risk for positive or equivocal margins after WLE.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Neoplasias de Cabeça e Pescoço
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Melanoma
Tipo de estudo:
Etiology_studies
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Guideline
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article