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Ivermectin activates GIRK channels in a PIP2 -dependent, Gßγ -independent manner and an amino acid residue at the slide helix governs the activation.
Chen, I-Shan; Tateyama, Michihiro; Fukata, Yuko; Uesugi, Motonari; Kubo, Yoshihiro.
Afiliação
  • Chen IS; Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan.
  • Tateyama M; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, 240-0193, Japan.
  • Fukata Y; Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan.
  • Uesugi M; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, 240-0193, Japan.
  • Kubo Y; Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan.
J Physiol ; 595(17): 5895-5912, 2017 09 01.
Article em En | MEDLINE | ID: mdl-28715108
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ivermectina / Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G / Antiparasitários Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ivermectina / Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G / Antiparasitários Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article