Chemical UPLC-ESI-MS/MS profiling of aconitum alkaloids and their metabolites in rat plasma and urine after oral administration of Aconitum carmichaelii Debx. Root extract.

Zhang, Mingjie; Wang, Manman; Liang, Jiajia; Wen, Yongqing; Xiong, Zhili

Zhang, Mingjie; Wang, Manman; Liang, Jiajia; Wen, Yongqing; Xiong, Zhili.

Afiliação

Zhang M; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Wang M; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Liang J; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Wen Y; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Xiong Z; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

Biomed Chromatogr ; 32(2)2018 Feb.

Article em En | MEDLINE | ID: mdl-28718960

Assuntos

Aconitum/química; Alcaloides/sangue; Alcaloides/urina; Extratos Vegetais/farmacocinética; Administração Oral; Alcaloides/química; Alcaloides/farmacocinética; Animais; Cromatografia Líquida de Alta Pressão/métodos; Diterpenos; Medicamentos de Ervas Chinesas; Masculino; Extratos Vegetais/administração & dosagem; Raízes de Plantas/química; Ratos; Ratos Sprague-Dawley; Espectrometria de Massas em Tandem/métodos

Palavras-chave

UPLC-ESI-MS/MS; aconitum alkaloids; chemical profiling; metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Aconitum / Alcaloides Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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