Trachomatous Scar Ranking: A Novel Outcome for Trachoma Studies.
Am J Trop Med Hyg
; 96(6): 1378-1381, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28719271
ABSTRACT
AbstractWe evaluated a new trachoma scarring ranking system with potential use in clinical research. The upper right tarsal conjunctivas of 427 individuals from Ethiopian villages with hyperendemic trachoma were photographed. An expert grader first assigned a scar grade to each photograph using the 1981 World Health Organization (WHO) grading system. Then, all photographs were ranked from least (rank = 1) to most scarring (rank = 427). Photographic grading found 79 (18.5%) conjunctivae without scarring (C0), 191 (44.7%) with minimal scarring (C1), 105 (24.6%) with moderate scarring (C2), and 52 (12.2%) with severe scarring (C3). The ranking method demonstrated good internal validity, exhibiting a monotonic increase in the median rank across the levels of the 1981 WHO grading system. Intrarater repeatability was better for the ranking method (intraclass correlation coefficient = 0.84, 95% CI = 0.74-0.94). Exhibiting better internal and external validity, this ranking method may be useful for evaluating the difference in scarring between groups of individuals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tracoma
/
Cicatriz
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Child
/
Female
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Humans
/
Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article