Asymmetric synthesis and evaluation of epoxy-&#945;-acyloxycarboxamides as selective inhibitors of cathepsin L.

Dos Santos, Deborah A; Deobald, Anna Maria; Cornelio, Vivian E; Ávila, Roberta M D; Cornea, Renata C; Bernasconi, Gilberto C R; Paixão, Marcio W; Vieira, Paulo C; Corrêa, Arlene G

Asymmetric synthesis and evaluation of epoxy-α-acyloxycarboxamides as selective inhibitors of cathepsin L.

Dos Santos, Deborah A; Deobald, Anna Maria; Cornelio, Vivian E; Ávila, Roberta M D; Cornea, Renata C; Bernasconi, Gilberto C R; Paixão, Marcio W; Vieira, Paulo C; Corrêa, Arlene G.

Afiliação

Dos Santos DA; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
Deobald AM; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
Cornelio VE; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
Ávila RMD; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
Cornea RC; Advanced Centre for Study and Research - CAEP, 13087-567 Campinas, SP, Brazil.
Bernasconi GCR; Advanced Centre for Study and Research - CAEP, 13087-567 Campinas, SP, Brazil.
Paixão MW; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
Vieira PC; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
Corrêa AG; Centre of Excellence for Research in Sustainable Chemistry - CERSusChem, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil. Electronic address: agcorrea@ufscar.br.

Bioorg Med Chem ; 25(17): 4620-4627, 2017 09 01.

Article em En | MEDLINE | ID: mdl-28720327

Assuntos

Amidas/química; Catepsina L/antagonistas & inibidores; Inibidores de Cisteína Proteinase/síntese química; Amidas/metabolismo; Amidas/farmacologia; Animais; Antiparasitários/química; Antiparasitários/metabolismo; Antiparasitários/farmacologia; Catepsina L/metabolismo; Inibidores de Cisteína Proteinase/metabolismo; Inibidores de Cisteína Proteinase/farmacologia; Concentração Inibidora 50; Parasitos/efeitos dos fármacos; Parasitos/enzimologia; Estereoisomerismo; Relação Estrutura-Atividade

Palavras-chave

Cathepsin L inhibitor; Epoxipeptidomimetics; Green synthesis; Tight binding inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Cisteína Proteinase / Catepsina L / Amidas Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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