Organ retention of gadolinium in mother and pup mice: effect of pregnancy and type of gadolinium-based contrast agents.
Jpn J Radiol
; 35(10): 568-573, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28730467
ABSTRACT
PURPOSE:
To investigate the effect of pregnancy and type of gadolinium (Gd)-based contrast agents (GBCAs) on organ retention of Gd in mother and pup mice after maternal administration. MATERIALS ANDMETHODS:
Gd-DTPA-BMA (gadodiamide) or Gd-DOTA (gadoterate dimeglumine) was administered (2.0 mmol/kg of maternal weight) four times to pregnant Balb/c mice from gestational day 16-19, respectively. At 28 days after birth, they were euthanized and their organs (blood, brain, liver, kidney, spleen, and bone) were removed for the measurement of Gd by inductively coupled plasma mass spectrometry.RESULTS:
Gd retention in maternal organs was generally lower than that in the organs of non-pregnant mice in both Gd-DTPA-BMA and Gd-DOTA groups. Significantly higher Gd retention was observed in the organs of pups whose mothers were administered Gd-DTPA-BMA as compared to those whose mothers were administered Gd-DOTA. Tissue-to-muscle ratio in the brains of pups was higher than that of mothers.CONCLUSION:
We demonstrated in utero transplacental Gd retention in pups. In various organs in both mothers and pups, Gd retention was consistently higher for Gd-DTPA-BMA than Gd-DOTA administration. Pregnancy affected Gd retention in many maternal organs.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Meios de Contraste
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Gadolínio DTPA
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Compostos Heterocíclicos
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Troca Materno-Fetal
Limite:
Animals
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Pregnancy
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article