Enzymatic Synthesis of Homogeneous Chondroitin Sulfate Oligosaccharides.
Angew Chem Int Ed Engl
; 56(39): 11784-11787, 2017 09 18.
Article
em En
| MEDLINE
| ID: mdl-28731518
ABSTRACT
Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiological roles. Here, we report an enzyme-based method for the synthesis of a library of 15 different CS oligosaccharides. This library covers 4-O-sulfated and 6-O-sulfated oligosaccharides ranging from trisaccharides to nonasaccharides. We also describe the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing either a 6-O-sulfo-2-azidogalactosamine or a 6-O-sulfogalactosamine residue. The availability of structurally defined CS oligosaccharides offers a novel approach to investigate the biological functions of CS.
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Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
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Sulfotransferases
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Sulfatos de Condroitina
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article