The role of oxysterol-binding protein and its related proteins in cancer.
Semin Cell Dev Biol
; 81: 149-153, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-28733164
ABSTRACT
Oxysterol-binding protein (OSBP) and its related proteins (ORPs) constitute a large, evolutionarily conserved family of lipid-binding proteins that are associated with a wide range of cellular activities. The core function of OSBP/ORPs appears to be moving lipids between cellular membranes in a non-vesicular manner. Recent studies have unveiled a novel, counter-transport mechanism of cellular lipid transfer mediated by OSBP/ORPs at the membrane contact sites that involves phosphatidylinositol 4-phosphate. Importantly, the OSBP/ORPs family has also been implicated in cell signalling pathways and cancer development. Here, we summarize recent progress in understanding the role of OSBP/ORPs in cancer development, and discuss how the lipid transfer function of OSBP/ORPs may underpin their role in tumorigenesis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Receptores de Esteroides
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Metabolismo dos Lipídeos
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Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article