Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aß1-42-induced neuroinflammation and neurodegeneration via the NF-KB /JNK/GSK3ß signaling pathway.
Nanomedicine
; 13(8): 2533-2544, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28736294
ABSTRACT
Amyloid-beta (Aß1-42) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanoparticles (PEG-AuNPs) in Aß1-42-injected mouse and in vitro models of AD. We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced Aß1-42-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-κB/p-GSK3ß pathway in both in vivo and in vitro AD models. However, anthocyanins loaded with PEG-AuNPs were more effective compared to anthocyanins alone. Taken together, these results demonstrate that PEG-coated gold anthocyanins nanoparticles could be a new therapeutic agent in the field of nanomedicine to prevent neurodegenerative diseases such as AD.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Peptídeos beta-Amiloides
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Fármacos Neuroprotetores
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Nanopartículas Metálicas
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Doença de Alzheimer
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Ouro
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Inflamação
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Antocianinas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article