Reductive Etherification via Anion-Binding Catalysis.
J Am Chem Soc
; 139(30): 10224-10227, 2017 08 02.
Article
em En
| MEDLINE
| ID: mdl-28741943
ABSTRACT
Reductive condensations of alcohols with aldehydes/ketones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates in combination with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing reagent. This strategy is applicable to challenging substrate combinations and exhibits functional group tolerance. Competing reductive homocoupling of the carbonyl component is suppressed.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article